Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

BACKGROUND: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bon...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Marino, Silvia, de Ridder, Daniëlle, Bishop, Ryan T., Renema, Nathalie, Ponzetti, Marco, Sophocleous, Antonia, Capulli, Mattia, Aljeffery, Abdullah, Carrasco, Giovana, Gens, Marianela Dalghi, Khogeer, Asim, Ralston, Stuart H., Gertsch, Jürg, Lamoureux, Francois, Heymann, Dominique, Rucci, Nadia, Idris, Aymen I.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606522/
https://ncbi.nlm.nih.gov/pubmed/31151929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.048
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