Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

BACKGROUND: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bon...

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Enregistré dans:
Détails bibliographiques
Publié dans:EBioMedicine
Auteurs principaux: Marino, Silvia, de Ridder, Daniëlle, Bishop, Ryan T., Renema, Nathalie, Ponzetti, Marco, Sophocleous, Antonia, Capulli, Mattia, Aljeffery, Abdullah, Carrasco, Giovana, Gens, Marianela Dalghi, Khogeer, Asim, Ralston, Stuart H., Gertsch, Jürg, Lamoureux, Francois, Heymann, Dominique, Rucci, Nadia, Idris, Aymen I.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2019
Sujets:
Research paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606522/
https://ncbi.nlm.nih.gov/pubmed/31151929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.048
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