Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

BACKGROUND: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bon...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Marino, Silvia, de Ridder, Daniëlle, Bishop, Ryan T., Renema, Nathalie, Ponzetti, Marco, Sophocleous, Antonia, Capulli, Mattia, Aljeffery, Abdullah, Carrasco, Giovana, Gens, Marianela Dalghi, Khogeer, Asim, Ralston, Stuart H., Gertsch, Jürg, Lamoureux, Francois, Heymann, Dominique, Rucci, Nadia, Idris, Aymen I.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606522/
https://ncbi.nlm.nih.gov/pubmed/31151929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.048
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