Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

BACKGROUND: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bon...

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發表在:EBioMedicine
Main Authors: Marino, Silvia, de Ridder, Daniëlle, Bishop, Ryan T., Renema, Nathalie, Ponzetti, Marco, Sophocleous, Antonia, Capulli, Mattia, Aljeffery, Abdullah, Carrasco, Giovana, Gens, Marianela Dalghi, Khogeer, Asim, Ralston, Stuart H., Gertsch, Jürg, Lamoureux, Francois, Heymann, Dominique, Rucci, Nadia, Idris, Aymen I.
格式: Artigo
語言:Inglês
出版: Elsevier 2019
主題:
Research paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606522/
https://ncbi.nlm.nih.gov/pubmed/31151929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.048
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