Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing miceResearch in context

Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bon...

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Main Authors: Silvia Marino, Daniëlle de Ridder, Ryan T. Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H. Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I. Idris
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-06-01
Colecção:EBioMedicine
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396419303561
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