JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice

Multiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation. Pharmacological manipulation of monoacylglycerol lipase (MAGL), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (...

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Publicat a:Calcif Tissue Int
Autors principals: Marino, Silvia, Carrasco, Giovana, Li, Boya, Shah, Karan M., Lath, Darren L., Sophocleous, Antonia, Lawson, Michelle A., Idris, Aymen I.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271071/
https://ncbi.nlm.nih.gov/pubmed/32285169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-020-00689-0
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