Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis

Streptococcus pyogenes (Group A streptococcus; GAS) is a human pathogen causing diseases from uncomplicated tonsillitis to life-threatening invasive infections. GAS secretes EndoS, an endoglycosidase that specifically cleaves the conserved N-glycan on IgG antibodies. In vitro, removal of this glycan...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Naegeli, Andreas, Bratanis, Eleni, Karlsson, Christofer, Shannon, Oonagh, Kalluru, Raja, Linder, Adam, Malmström, Johan, Collin, Mattias
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605743/
https://ncbi.nlm.nih.gov/pubmed/31092533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190293
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