Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis

BACKGROUND: The human pathogen Streptococcus pyogenes produces an endoglycosidase, EndoS that hydrolyzes the chitobiose core of the asparagine-linked glycan on the heavy chain of human IgG. IgG-binding to Fc gamma receptors (FcγR) on leukocytes triggers effector functions including phagocytosis, oxi...

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Bibliographic Details
Main Authors: Allhorn, Maria, Olin, Anders I., Nimmerjahn, Falk, Collin, Mattias
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173940/
https://ncbi.nlm.nih.gov/pubmed/18183294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001413
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