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EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity

BACKGROUND: The endoglycosidase EndoS and the cysteine proteinase SpeB from the human pathogen Streptococcus pyogenes are functionally related in that they both hydrolyze IgG leading to impairment of opsonizing antibodies and thus enhance bacterial survival in human blood. In this study, we further...

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Main Authors: Allhorn, Maria, Olsén, Arne, Collin, Mattias
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266755/
https://ncbi.nlm.nih.gov/pubmed/18182097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-8-3
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