Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein

Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson's disease (PD) pathogenesis. We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. Here we report markedly decreased APP...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ayton, Scott, Lei, Peng, Hare, Dominic J., Duce, James A., George, Jessica L., Adlard, Paul A., McLean, Catriona, Rogers, Jack T., Cherny, Robert A., Finkelstein, David I., Bush, Ashley I.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605561/
https://ncbi.nlm.nih.gov/pubmed/25716857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3439-14.2015
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