A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children

Recently a framework was presented to assess whether pediatric covariate models for clearance can be extrapolated between drugs sharing elimination pathways, based on extraction ratio, protein binding, and other drug properties. Here we evaluate when a pediatric covariate function for midazolam clea...

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Опубликовано в: :AAPS J
Главные авторы: Brussee, Janneke M., Krekels, Elke H. J., Calvier, Elisa A. M., Palić, Semra, Rostami-Hodjegan, Amin, Danhof, Meindert, Barrett, Jeffrey S., de Wildt, Saskia N., Knibbe, Catherijne A. J.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597607/
https://ncbi.nlm.nih.gov/pubmed/31250333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0351-9
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