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First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants. On the basis of midazolam and 1‐OH‐midazolam conc...

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Bibliografiske detaljer
Udgivet i:CPT Pharmacometrics Syst Pharmacol
Main Authors: Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., de Roos, Berend, Brill, Margreke J. E., van den Anker, Johannes N., Rostami‐Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027733/
https://ncbi.nlm.nih.gov/pubmed/29745466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12295
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