First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants. On the basis of midazolam and 1‐OH‐midazolam conc...

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Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., de Roos, Berend, Brill, Margreke J. E., van den Anker, Johannes N., Rostami‐Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027733/
https://ncbi.nlm.nih.gov/pubmed/29745466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12295
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