A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children

Recently a framework was presented to assess whether pediatric covariate models for clearance can be extrapolated between drugs sharing elimination pathways, based on extraction ratio, protein binding, and other drug properties. Here we evaluate when a pediatric covariate function for midazolam clea...

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Xehetasun bibliografikoak
Argitaratua izan da:AAPS J
Egile Nagusiak: Brussee, Janneke M., Krekels, Elke H. J., Calvier, Elisa A. M., Palić, Semra, Rostami-Hodjegan, Amin, Danhof, Meindert, Barrett, Jeffrey S., de Wildt, Saskia N., Knibbe, Catherijne A. J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer International Publishing 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597607/
https://ncbi.nlm.nih.gov/pubmed/31250333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0351-9
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