Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Phosphorylation of dynamin-related protein 1 (Drp1) represents an important regulatory mechanism for mitochondrial fission. Here, we established the role of Drp1 serine 600 (Drp1S600) phosphorylation in mitochondrial fission in vivo and assessed the functional consequences of targeted elimination of...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Galvan, Daniel L., Long, Jianyin, Green, Nathanael, Chang, Benny H., Lin, Jamie S., Schumacker, Paul, Truong, Luan D., Overbeek, Paul, Danesh, Farhad R.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597204/
https://ncbi.nlm.nih.gov/pubmed/31063459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127277
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