Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Phosphorylation of dynamin-related protein 1 (Drp1) represents an important regulatory mechanism for mitochondrial fission. Here, we established the role of Drp1 serine 600 (Drp1S600) phosphorylation in mitochondrial fission in vivo and assessed the functional consequences of targeted elimination of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Galvan, Daniel L., Long, Jianyin, Green, Nathanael, Chang, Benny H., Lin, Jamie S., Schumacker, Paul, Truong, Luan D., Overbeek, Paul, Danesh, Farhad R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597204/
https://ncbi.nlm.nih.gov/pubmed/31063459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127277
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