Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular complications of diabetes, including diabetic nephropathy. However, the signaling pathways by which hyperglycemia leads to mitochondrial dysfunction are not fully understood. H...

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Главные авторы: Wang, Wenjian, Wang, Yin, Long, Jianyin, Wang, Jinrong, Haudek, Sandra B., Overbeek, Paul, Chang, Benny H.J., Schumacker, Paul T., Danesh, Farhad R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278719/
https://ncbi.nlm.nih.gov/pubmed/22326220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.01.009
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