Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents

Podophyllotoxin has long been used as an active substance for cytotoxic activity. Fourteen novel biotinylated podophyllotoxin derivatives were designed, synthesized, and evaluated for cytotoxic activity for this study. The synthesized compounds were evaluated for cytotoxic activity in the following...

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Bibliografische gegevens
Gepubliceerd in:Front Chem
Hoofdauteurs: Zi, Cheng-Ting, Gao, Ying-Sheng, Yang, Liu, Feng, Shu-Yun, Huang, Yue, Sun, Li, Jin, Yi, Xu, Feng-Qing, Dong, Fa-Wu, Li, Yan, Ding, Zhong-Tao, Zhou, Jun, Jiang, Zi-Hua, Yuan, Sheng-Tao, Hu, Jiang-Miao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596340/
https://ncbi.nlm.nih.gov/pubmed/31281809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00434
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