Synthesis and anticancer activity of dimeric podophyllotoxin derivatives

BACKGROUND: Podophyllotoxin is a potent cytotoxic agent and serves as a useful lead compound for the development of antitumor drugs. Several podophyllotoxin-derived antitumor agents, including etoposide, are currently in clinical use; however, their therapeutic efficacy is often limited due to side...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Zi, Cheng-Ting, Yang, Liu, Xu, Feng-Qing, Dong, Fa-Wu, Yang, Dan, Li, Yan, Ding, Zhong-Tao, Zhou, Jun, Jiang, Zi-Hua, Hu, Jiang-Miao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186772/
https://ncbi.nlm.nih.gov/pubmed/30349193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S167382
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