Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides

A series of novel 4β-triazole-podophyllotoxin glycosides were synthesized by utilizing the Click reaction. Evaluation of cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assay shows that most of these compounds show weak cytotoxicity. It...

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Bibliographic Details
Published in:Nat Prod Bioprospect
Main Authors: Zi, Cheng-Ting, Li, Gen-Tao, Li, Yan, Zhou, Jun, Ding, Zhong-Tao, Jiang, Zi-Hua, Hu, Jiang-Miao
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402586/
https://ncbi.nlm.nih.gov/pubmed/25869591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13659-015-0057-3
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