Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel with the onset of innate antimicrobial defenses, but the contribution of IL-1β signaling to cell-intrinsic immunity is no...

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Publicado en:Mol Cell
Main Authors: Aarreberg, Lauren D., Esser-Nobis, Katharina, Driscoll, Connor, Shuvarikov, Andrey, Roby, Justin A., Gale, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596306/
https://ncbi.nlm.nih.gov/pubmed/30952515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.038
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