Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway

Abstract Background Cervical cancer (CC) remains a significant global health challenge for women, especially in advanced stages where effective treatments are limited. Current immunotherapies, including PD-1/PD-L1 blockades and adoptive T cell therapies, show limited response rates and durability. D...

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Main Authors: Han Jiang, Liting Liu, Shan He, Shen Qu, Yifan Yang, Guijie Kang, Min Wu, Hangyu Liu, Yuwei Zhang, Zixuan Wang, Wenjing Tian, Ying Chen, Liming Wang, Qiangqiang Wang, Ting Ye, Junyan Han, Hui Wang, Yafei Huang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-10-01
Colecção:Journal of Biomedical Science
Assuntos:
Immunotherapy
CD8+ T
CXCL10
CCL5
Dimethyl fumarate
Cervical cancer
Acesso em linha:https://doi.org/10.1186/s12929-025-01187-x
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