Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway

Abstract Background Cervical cancer (CC) remains a significant global health challenge for women, especially in advanced stages where effective treatments are limited. Current immunotherapies, including PD-1/PD-L1 blockades and adoptive T cell therapies, show limited response rates and durability. D...

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Autori principali:	Han Jiang, Liting Liu, Shan He, Shen Qu, Yifan Yang, Guijie Kang, Min Wu, Hangyu Liu, Yuwei Zhang, Zixuan Wang, Wenjing Tian, Ying Chen, Liming Wang, Qiangqiang Wang, Ting Ye, Junyan Han, Hui Wang, Yafei Huang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-10-01
Serie:	Journal of Biomedical Science
Soggetti:	Immunotherapy CD8+ T CXCL10 CCL5 Dimethyl fumarate Cervical cancer
Accesso online:	https://doi.org/10.1186/s12929-025-01187-x
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