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ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB) therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA double-stranded breaks (DSBs) and coordinating their repair. Recent data indicated that ATM might be a promising target to en...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7843232/ https://ncbi.nlm.nih.gov/pubmed/33290271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI139333 |
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