ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation

Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB) therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA double-stranded breaks (DSBs) and coordinating their repair. Recent data indicated that ATM might be a promising target to en...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Hu, Mengjie, Zhou, Min, Bao, Xuhui, Pan, Dong, Jiao, Meng, Liu, Xinjian, Li, Fang, Li, Chuan-Yuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843232/
https://ncbi.nlm.nih.gov/pubmed/33290271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI139333
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