Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel with the onset of innate antimicrobial defenses, but the contribution of IL-1β signaling to cell-intrinsic immunity is no...

Full description

Saved in:
Bibliographic Details
Published in:Mol Cell
Main Authors: Aarreberg, Lauren D., Esser-Nobis, Katharina, Driscoll, Connor, Shuvarikov, Andrey, Roby, Justin A., Gale, Michael
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596306/
https://ncbi.nlm.nih.gov/pubmed/30952515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.038
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items