Rapamycin reverses metabolic deficits in Lamin A/C-deficient mice

The role of the mTOR inhibitor rapamycin in regulation of adiposity remains controversial. Here, we evaluate mTOR signaling in lipid metabolism in adipose tissues of Lmna(−/−)mice, a mouse model for dilated cardiomyopathy and muscular dystrophy. Lifespan extension by rapamycin is associated with inc...

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Udgivet i:Cell Rep
Main Authors: Liao, Chen-Yu, Anderson, Sydney S., Chicoine, Nicole H., Mayfield, Jarrott R., Academia, Emmeline C., O’Leary, Monique N., Wilson, Joy A., Pongkietisak, Chalermkwan, Thompson, Morgan A., Lagmay, Earl P., Hsu, Yueh-Mei, Miller, Delana M., Kennedy, Brian K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594831/
https://ncbi.nlm.nih.gov/pubmed/27926859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.040
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