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Rapamycin reverses metabolic deficits in Lamin A/C-deficient mice
The role of the mTOR inhibitor rapamycin in regulation of adiposity remains controversial. Here, we evaluate mTOR signaling in lipid metabolism in adipose tissues of Lmna(−/−)mice, a mouse model for dilated cardiomyopathy and muscular dystrophy. Lifespan extension by rapamycin is associated with inc...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594831/ https://ncbi.nlm.nih.gov/pubmed/27926859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.040 |
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