Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

Por Schreiber, Katherine H, Ortiz, Denise, Academia, Emmeline C, Anies, Arieanna C, Liao, Chen-Yu, Kennedy, Brian K
Publicado no Aging Cell (2015)

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo

Por Garelick, Michael G, MacKay, Vivian L, Yanagida, Aya, Academia, Emmeline C, Schreiber, Katherine H, Ladiges, Warren C, Kennedy, Brian K
Publicado em 2013

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Por Tsai, Shihyin, Sitzmann, Joanna M., Dastidar, Somasish G., Rodriguez, Ariana A., Vu, Stephanie L., McDonald, Circe E., Academia, Emmeline C., O’Leary, Monique N., Ashe, Travis D., La Spada, Albert R., Kennedy, Brian K.
Publicado no J Clin Invest (2015)

Late-life rapamycin treatment reverses age-related heart dysfunction

Por Flynn, James M., O’Leary, Monique N., Zambataro, Christopher A., Academia, Emmeline C., Presley, Michael P., Garrett, Brittany J., Zykovich, Artem, Mooney, Sean D., Strong, Randy, Rosen, Clifford J., Kapahi, Pankaj, Nelson, Michael D., Kennedy, Brian K., Melov, Simon
Publicado em 2013

Increased 4E-BP1 expression protects against diet-induced obesity and insulin resistance in male mice

Por Tsai, Shih-Yin, Rodriguez, Ariana A., Dastidar, Somasish G., Del Greco, Elizabeth, Carr, Kaili Lia, Sitzmann, Joanna M., Academia, Emmeline C., Viray, Christian Michael, Martinez, Lizbeth Leon, Kaplowitz, Brian Stephen, Ashe, Travis D., La Spada, Albert R., Kennedy, Brian K.
Publicado no Cell Rep (2016)

The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1

Por O'Leary, Monique N., Schreiber, Katherine H., Zhang, Yong, Duc, Anne-Cécile E., Rao, Shuyun, Hale, J. Scott, Academia, Emmeline C., Shah, Shreya R., Morton, John F., Holstein, Carly A., Martin, Dan B., Kaeberlein, Matt, Ladiges, Warren C., Fink, Pamela J., MacKay, Vivian L., Wiest, David L., Kennedy, Brian K.
Publicado em 2013

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Por Demaria, Marco, O’Leary, Monique N., Chang, Jianhui, Shao, Lijian, Liu, Su, Alimirah, Fatouma, Koenig, Kristin, Le, Catherine, Mitin, Natalia, Deal, Allison M., Alston, Shani, Academia, Emmeline C., Kilmarx, Sumner, Valdovinos, Alexis, Wang, Boshi, de Bruin, Alain, Kennedy, Brian K., Melov, Simon, Zhou, Daohong, Sharpless, Norman E., Muss, Hyman, Campisi, Judith
Publicado no Cancer Discov (2016)