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Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo

Reducing activity of the mTORC1/S6K1 pathway has been shown to extend lifespan in both vertebrate and invertebrate models. For instance, both pharmacological inhibition of mTORC1 with the drug rapamycin or S6K1 knockout extends lifespan in mice. Since studies with invertebrate models suggest that re...

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Detalhes bibliográficos
Main Authors: Garelick, Michael G, MacKay, Vivian L, Yanagida, Aya, Academia, Emmeline C, Schreiber, Katherine H, Ladiges, Warren C, Kennedy, Brian K
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841327/
https://ncbi.nlm.nih.gov/pubmed/23839034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25512
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