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Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
The mechanism by which the drug rapamycin inhibits the mechanistic target of rapamycin (mTOR) is of intense interest because of its likely relevance in cancer biology, aging, and other age-related diseases. While rapamycin acutely and directly inhibits mTORC1, only chronic administration of rapamyci...
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| Publicado en: | Aging Cell |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364838/ https://ncbi.nlm.nih.gov/pubmed/25652038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12313 |
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