Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent cells acquire a pro-inflammatory senescence-associated secretory phenotype. Many genotoxic chemotherapies target proliferating cells non-specifically, often with adverse reactions. In accord with prior work...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Demaria, Marco, O’Leary, Monique N., Chang, Jianhui, Shao, Lijian, Liu, Su, Alimirah, Fatouma, Koenig, Kristin, Le, Catherine, Mitin, Natalia, Deal, Allison M., Alston, Shani, Academia, Emmeline C., Kilmarx, Sumner, Valdovinos, Alexis, Wang, Boshi, de Bruin, Alain, Kennedy, Brian K., Melov, Simon, Zhou, Daohong, Sharpless, Norman E., Muss, Hyman, Campisi, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296251/
https://ncbi.nlm.nih.gov/pubmed/27979832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0241
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