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Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells
Tissue homeostasis declines with age partly because stem/progenitor cells fail to self-renew or differentiate. Because mitochondrial damage can accelerate aging, we tested the hypothesis that mitochondrial dysfunction impairs stem cell renewal or function. We developed a mouse model, Tg(KRT14-cre/Es...
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| 發表在: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547253/ https://ncbi.nlm.nih.gov/pubmed/26240345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505675112 |
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