Late-life rapamycin treatment reverses age-related heart dysfunction

Rapamycin has been shown to extend lifespan in numerous model organisms including mice, with the most dramatic longevity effects reported in females. However, little is known about the functional ramifications of this longevity-enhancing paradigm in mammalian tissues. We treated 24-month-old female...

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Autors principals: Flynn, James M., O’Leary, Monique N., Zambataro, Christopher A., Academia, Emmeline C., Presley, Michael P., Garrett, Brittany J., Zykovich, Artem, Mooney, Sean D., Strong, Randy, Rosen, Clifford J., Kapahi, Pankaj, Nelson, Michael D., Kennedy, Brian K., Melov, Simon
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098908/
https://ncbi.nlm.nih.gov/pubmed/23734717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12109
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