Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins

The mechanistic target of rapamycin (mTOR) signaling pathway plays a central role in aging and a number of different disease states. Rapamycin, which suppresses activity of the mTOR complex 1 (mTORC1), shows preclinical (and sometimes clinical) efficacy in a number of disease models. Among these are...

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Udgivet i:Cell Discov
Main Authors: Liao, Chen-Yu, Anderson, Sydney S, Chicoine, Nicole H, Mayfield, Jarrott R, Garrett, Brittany J, Kwok, Charlotte S, Academia, Emmeline C, Hsu, Yueh-Mei, Miller, Delana M, Bair, Amanda M, Wilson, Joy A, Tannady, Gabriella, Stewart, Erin M, Adamson, Stuart S, Wang, Junying, Withers, Dominic J, Kennedy, Brian K
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931234/
https://ncbi.nlm.nih.gov/pubmed/29736257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2017.39
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