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Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage
Lamins A/C have been implicated in DNA damage response pathways. We show that the DNA repair protein 53BP1 is a lamin A/C binding protein. In undamaged human dermal fibroblasts (HDF), 53BP1 is a nucleoskeleton protein. 53BP1 binds to lamins A/C via its Tudor domain, and this is abrogated by DNA dama...
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| Publicado no: | Aging Cell |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364828/ https://ncbi.nlm.nih.gov/pubmed/25645366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12258 |
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