Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

Lamins A/C have been implicated in DNA damage response pathways. We show that the DNA repair protein 53BP1 is a lamin A/C binding protein. In undamaged human dermal fibroblasts (HDF), 53BP1 is a nucleoskeleton protein. 53BP1 binds to lamins A/C via its Tudor domain, and this is abrogated by DNA dama...

Full description

Saved in:
Bibliographic Details
Published in:Aging Cell
Main Authors: Gibbs-Seymour, Ian, Markiewicz, Ewa, Bekker-Jensen, Simon, Mailand, Niels, Hutchison, Christopher J
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364828/
https://ncbi.nlm.nih.gov/pubmed/25645366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12258
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items