The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells

Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. The effect of different p53-activating chemotherapeutic drugs on CYP1A1 expression, and the resultant effect on BaP metabolism, was investigated in a panel of isogenic...

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Publicado no:Toxicology
Main Authors: Willis, Alexandra J., Indra, Radek, Wohak, Laura E., Sozeri, Osman, Feser, Kerstin, Mrizova, Iveta, Phillips, David H., Stiborova, Marie, Arlt, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593262/
https://ncbi.nlm.nih.gov/pubmed/29471073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2018.02.006
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