Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine

ABSTRACT: Cytochrome P450 (CYP) 2S1 is “orphan” CYP that is overexpressed in several epithelial tissues and many human tumors. The pure enzyme is required for better understanding of its biological functions. Therefore, human CYP2S1 was considered to be prepared by the gene manipulations and heterol...

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Опубликовано в: :Monatsh Chem
Главные авторы: Mrízová, Iveta, Moserová, Michaela, Milichovský, Jan, Šulc, Miroslav, Kizek, René, Kubáčková, Kateřina, Arlt, Volker M., Stiborová, Marie
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Vienna 2016
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828499/
https://ncbi.nlm.nih.gov/pubmed/27110039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-016-1738-2
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