Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine

ABSTRACT: Cytochrome P450 (CYP) 2S1 is “orphan” CYP that is overexpressed in several epithelial tissues and many human tumors. The pure enzyme is required for better understanding of its biological functions. Therefore, human CYP2S1 was considered to be prepared by the gene manipulations and heterol...

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Detalhes bibliográficos
Publicado no:Monatsh Chem
Main Authors: Mrízová, Iveta, Moserová, Michaela, Milichovský, Jan, Šulc, Miroslav, Kizek, René, Kubáčková, Kateřina, Arlt, Volker M., Stiborová, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828499/
https://ncbi.nlm.nih.gov/pubmed/27110039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-016-1738-2
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