NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1

ABSTRACT: Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after metabolic activation by cytochrome P450 (CYP) enzymes. Here we investigated the efficiencies of rat hepatic microsomes and rat recombinant CYP1A1 expressed with its reductase, NADPH:CYP oxidoreductase (POR), NADH...

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Bibliografiset tiedot
Julkaisussa:Monatsh Chem
Päätekijät: Stiborová, Marie, Indra, Radek, Moserová, Michaela, Šulc, Miroslav, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H., Arlt, Volker M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Vienna 2016
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Original Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828493/
https://ncbi.nlm.nih.gov/pubmed/27110038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-016-1713-y
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