NADH:Cytochrome b(5) Reductase and Cytochrome b(5) Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene

[Image: see text] Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after activation by cytochrome P450 (P450). Here, we investigated whether NADH:cytochrome b(5) reductase (CBR) in the presence of cytochrome b(5) can act as sole electron donor to human P450 1A1 during BaP oxid...

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Publicado en:Chem Res Toxicol
Autores principales: Stiborová, Marie, Indra, Radek, Moserová, Michaela, Frei, Eva, Schmeiser, Heinz H., Kopka, Klaus, Philips, David H., Arlt, Volker M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987862/
https://ncbi.nlm.nih.gov/pubmed/27404282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00143
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