Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice

Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cytochrome b(5)/P450 Reductase Null (HBRN) mice have b...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Reed, Lindsay, Mrizova, Iveta, Barta, Frantisek, Indra, Radek, Moserova, Michaela, Kopka, Klaus, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Genotoxicity and Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882632/
https://ncbi.nlm.nih.gov/pubmed/29368147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2162-7
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