Application of hepatic cytochrome b(5)/P450 reductase null (HBRN) mice to study the role of cytochrome b(5) in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b(5) (Cyb5), electron donors to P450 enzymes, in the CYP-mediated metabolism and di...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Toxicol Appl Pharmacol
Egile Nagusiak: Reed, Lindsay, Indra, Radek, Mrizova, Iveta, Moserova, Michaela, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Academic Press 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382462/
https://ncbi.nlm.nih.gov/pubmed/30685480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.01.020
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