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Application of hepatic cytochrome b(5)/P450 reductase null (HBRN) mice to study the role of cytochrome b(5) in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b(5) (Cyb5), electron donors to P450 enzymes, in the CYP-mediated metabolism and di...

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Bibliografski detalji
Izdano u:Toxicol Appl Pharmacol
Glavni autori: Reed, Lindsay, Indra, Radek, Mrizova, Iveta, Moserova, Michaela, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Format: Artigo
Jezik:Inglês
Izdano: Academic Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382462/
https://ncbi.nlm.nih.gov/pubmed/30685480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.01.020
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