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Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice

Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cytochrome b(5)/P450 Reductase Null (HBRN) mice have b...

詳細記述

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書誌詳細
出版年:Arch Toxicol
主要な著者: Reed, Lindsay, Mrizova, Iveta, Barta, Frantisek, Indra, Radek, Moserova, Michaela, Kopka, Klaus, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
フォーマット: Artigo
言語:Inglês
出版事項: Springer Berlin Heidelberg 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882632/
https://ncbi.nlm.nih.gov/pubmed/29368147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2162-7
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