Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems

ABSTRACT: Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP). In the previous studies, we had shown that not only the canonic NADPH:CYP oxidoreductase (POR) can act as electron donor but also cytochrome b (5) and its reductase,...

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Detalhes bibliográficos
Publicado no:Monatsh Chem
Main Authors: Stiborová, Marie, Indra, Radek, Moserová, Michaela, Bořek-Dohalská, Lucie, Hodek, Petr, Frei, Eva, Kopka, Klaus, Schmeiser, Heinz H., Arlt, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653725/
https://ncbi.nlm.nih.gov/pubmed/29104317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-017-2002-0
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