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The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers
Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after metabolic activation by cytochrome P450 (CYP) enzymes. In this study human recombinant CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed in Supersomes™ together with their reductases, NADP...
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| 出版年: | Environ Mol Mutagen |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4855618/ https://ncbi.nlm.nih.gov/pubmed/26919089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22001 |
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