The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers

Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after metabolic activation by cytochrome P450 (CYP) enzymes. In this study human recombinant CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed in Supersomes™ together with their reductases, NADP...

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Bibliographische Detailangaben
Veröffentlicht in:Environ Mol Mutagen
Hauptverfasser: Šulc, Miroslav, Indra, Radek, Moserová, Michaela, Schmeiser, Heinz H., Frei, Eva, Arlt, Volker M., Stiborová, Marie, White, P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Brief Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855618/
https://ncbi.nlm.nih.gov/pubmed/26919089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22001
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