The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice

The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransfo...

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Détails bibliographiques
Publié dans:Arch Toxicol
Auteurs principaux: Krais, Annette M., Speksnijder, Ewoud N., Melis, Joost P. M., Indra, Radek, Moserova, Michaela, Godschalk, Roger W., van Schooten, Frederik-J., Seidel, Albrecht, Kopka, Klaus, Schmeiser, Heinz H., Stiborova, Marie, Phillips, David H., Luijten, Mirjam, Arlt, Volker M.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2015
Sujets:
Toxicokinetics and Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785204/
https://ncbi.nlm.nih.gov/pubmed/25995008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1531-8
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