Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT(1B) receptors

INTRODUCTION: The serotonin 1B receptor subtype is of interest in the pathophysiology and treatment of depression, anxiety, and migraine. Over recent years 5-HT(1B) receptor binding in human brain has been examined with PET using radio ligands that are partial but not full agonists. To explore how t...

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Publicado no:Nucl Med Biol
Main Authors: Lindberg, Anton, Lu, Shuiyu, Nag, Sangram, Schou, Magnus, Liow, Jeih-San, Zoghbi, Sami S., Frankland, Michael P., Gladding, Robert L, Morse, Cheryl L., Takano, Akihiro, Amini, Nahid, Elmore, Charles S., Lee, Yong Sok, Innis, Robert B., Halldin, Christer, Pike, Victor W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591083/
https://ncbi.nlm.nih.gov/pubmed/30811975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2019.01.005
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