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Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

Antimicrobial peptides (AMPs) have garnered much attention as novel therapeutic agents against infectious diseases. They exhibit antimicrobial activity through microbial membrane disruption based on their amphipathic properties. In this study, we rationally designed and synthesized a series of novel...

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Publicado en:Medchemcomm
Main Authors: Misawa, Takashi, Goto, Chihiro, Shibata, Norihito, Hirano, Motoharu, Kikuchi, Yutaka, Naito, Mikihiko, Demizu, Yosuke
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590335/
https://ncbi.nlm.nih.gov/pubmed/31303986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00166b
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