Inward-facing conformation of a multidrug resistance MATE family transporter

Multidrug and toxic compound extrusion (MATE) transporters mediate excretion of xenobiotics and toxic metabolites, thereby conferring multidrug resistance in bacterial pathogens and cancer cells. Structural information on the alternate conformational states and knowledge of the detailed mechanism of...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zakrzewska, Sandra, Mehdipour, Ahmad Reza, Malviya, Viveka Nand, Nonaka, Tsuyoshi, Koepke, Juergen, Muenke, Cornelia, Hausner, Winfried, Hummer, Gerhard, Safarian, Schara, Michel, Hartmut
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589766/
https://ncbi.nlm.nih.gov/pubmed/31160466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904210116
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