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Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system
TipA is a transcriptional regulator found in diverse bacteria. It constitutes a minimal autoregulated multidrug resistance system against numerous thiopeptide antibiotics. Here we report the structures of its drug-binding domain TipAS in complexes with promothiocin A and nosiheptide, and a model of...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280590/ https://ncbi.nlm.nih.gov/pubmed/25489067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412070111 |
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