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Molecular basis for the recognition of the human AAUAAA polyadenylation signal

Nearly all eukaryotic messenger RNA precursors must undergo cleavage and polyadenylation at their 3′-end for maturation. A crucial step in this process is the recognition of the AAUAAA polyadenylation signal (PAS), and the molecular mechanism of this recognition has been a long-standing problem. Her...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sun, Yadong, Zhang, Yixiao, Hamilton, Keith, Manley, James L., Shi, Yongsheng, Walz, Thomas, Tong, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816196/
https://ncbi.nlm.nih.gov/pubmed/29208711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718723115
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